M. Devereux, M. Mccann, V. León
Nov 1, 2003
Citations
0
Influential Citations
16
Citations
Journal
Polyhedron
Abstract
Abstract Reactions of 2,2-dimethylpentanedioic acid(2dmepdaH2) and 3,3-dimethylpentanedioic acid (3dmepdaH2) with Mn(CH3COO)2 · 4H2O yield the soluble complexes [Mn(2dmepda)] · 1.5H2O (1) and [Mn(3dmepda)] · H2O (2). Complex 1 reacts with ethanolic solutions of 2,2′-bipyridine or 1,10-phenanthroline to give [Mn2(2dmepda)2(bipy)] · H2O (3) and [Mn(2dmepda)(phen)] (4), respectively. Similar reactions of 2 with these ligands generated [Mn2(3dmepda)2(bipy)3] · 5H2O (5) [Mn(3dmepda)(phen)2] · 7.25H2O (6). The molecular structure of 6 was determined by X-ray crystallography. The asymmetric unit contains two [Mn(3dmepda)(phen)2] units with 14.5 waters of crystallisation. The two manganese complexes are of very similar structure. In each case the manganese atom is ligated by four nitrogen atoms from two chelating phen molecules and two oxygen atoms, one from each of the carboxylates moieties of the 3dmepda2− ligand. Thus, the two carboxylate functions of the two 3dmepda2− dianionic ligands are essentially monodentate. The 2,2- and the 3,3-dimethylpentanedioate complexes, the metal free ligands and a number of simple manganese salts were each tested for their ability to inhibit the growth of Candida albicans. Only the “metal free” 1,10-phenanthroline and its 2,2- and the 3,3-dimethylpentanedioate complexes exhibit fungitoxic activity.