N. Lee, N. Kang, W. Cho
Sep 1, 2001
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0
Influential Citations
9
Citations
Journal
Polymer International
Abstract
A new monomer, exo-3,6-epoxy-1,2,3,6-tetrahydrophthalimidocaproic acid (ETCA), was prepared by reaction of maleimidocaproic acid and furan. The homopolymer of ETCA and its copolymers with acrylic acid (AA) or with vinyl acetate (VAc) were obtained by photopolymerizations using 2,2-dimethoxy-2-phenylacetophenone as an initiator at 25 °C. The synthesized ETCA and its polymers were identified by FTIR, 1H NMR and 13C NMR spectroscopies. The apparent average molecular weights and polydispersity indices determined by gel permeation chromatography (GPC) were as follows: Mn = 9600 g mol−1, Mw = 9800 g mol−1, Mw/Mn = 1.1 for poly(ETCA); Mn = 14 300 g mol−1, Mw = 16 200 g mol−1, Mw/Mn = 1.2 for poly(ETCA-co-AA); Mn = 17 900 g mol−1, Mw = 18 300 g mol−1, Mw/Mn = 1.1 for poly(ETCA-co-VAc). The in vitro cytotoxicity of the synthesized compounds against mouse mammary carcinoma and human histiocytic lymphoma cancer cell lines decreased in the following order: 5-fluorouracil (5-FU) ≥ ETCA > polymers. The in vivo antitumour activity of the polymers against Balb/C mice bearing sarcoma 180 tumour cells was greater than that of 5-FU at all doses tested. © 2001 Society of Chemical Industry