W. Al-Masoudi, Abeer Laily Mohmmed, W. H. Abass
Jun 30, 2015
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Journal
European Journal of Chemistry
Abstract
Condensation of 2-amino-4-chloro-6-methoxypyrimidine with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus , Escherichia coli , Bacillus subtilis , Klebsille , Pseudomonas aeruginosa and Salmonella . Additionally, the compounds were tested for antifungicidal activity against Candida albicans, Candida tropicalis and Aspergillus fumigatus . All compounds exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions.