M. Ibrahim, El-Hossain A. R. Mohamed, N. M. El-Gohary
Oct 31, 2011
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Abstract
Some new nitrogen bridge-head pyrido[1,2-b][1,2,4]triazepines incorporating 6methylchromone moiety have been synthesized from the reaction of 1,6-diamino-4-(6methyl-4-oxo-4H-chromen-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (4) with some α,γ-bifunctional electrophiles including 2-cyano-3,3-bis(methylthio)acrylonitrile, 2cyano-3,3-bis(methylthio)prop-2-enamide, 5-chloro-3-methyl-1-phenylpyrazole-4carboxaldehyde, 2-chloro-3-formylquinoline, p-methoxybenzylidene-malononitrile, ethyl 2cyano-3-(4-methoxyphenyl)prop-2-enoate, chromone-3-carbonitrile. Structures of the newly synthesized products have been deduced upon the help of elemental analysis and spectral data. The synthesized compounds were screened for their antimicrobial activity.