A. Saeed, Uzma Shaheen, A. Hameed
Mar 1, 2010
Citations
1
Influential Citations
22
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines ( 2a–t ) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas ( 1a–t ) with 2-bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria ( Staphylococcus aureus , Bacillus subtilis ) and Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa ). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species ( Rhizopus oryzae , Fusarium oxysporum , Aspergillus terreus , A. niger and A. fumigatus ).