M. Ibrahim, R. M. Abdel-Rahman, A. M. Abdel-Halim
Dec 10, 2008
Citations
0
Influential Citations
27
Citations
Journal
Arkivoc
Abstract
Amino-4-(4-chlorophenyl)-7-hydrazino-8H-pyrazolo(4,3-e)(1,2,4)triazolo(1`,5`-a)pyridine- 5-carbonitrile (4) was synthesized from 4-(4-chlorophenyl)-1,6-diamino-2-oxo-1,2-dihydro- pyridine-3,5-dicarbonitrile (1). Reaction of 4 with α,β-bifunctional compounds gave pyrazolotriazinotriazolopyridines (8-14). The behavior of 4 towards condensation reactions with indole-2,3-dione in different media gave different products 15-16. Acetylation of 16 led to different products depending on the reaction conditions. Structures of the products have been deduced from analytical and spectral data (UV, IR, 1 H NMR, 13 C NMR and mass spectra). Some of the products were screened for antifungal activity.