M. Mohamed
2004
Citations
1
Influential Citations
5
Citations
Journal
Bulgarian Chemical Communications
Abstract
3-Hydrazino-4-(2-methoxymethylphenyl)-6-aryl pyridazine was synthesized and its reactivity towards some reagents such as aliphatic, aromatic and heterocyclic anhydrides and aldehydes is reported. This compound was treatedwith α-diketones such as indole-2,3-dione (isatin), N-morpholinomethylisatin and N-piperidylmethylisatin to give the respective derivatives. 3-[N'-(2-oxo-l,3-dihydroindol-3-ylidene)hydrazino-4-(2-methoxymethylphenyl)-6-tolyl pyridazine was oxidized by selenium dioxide to give 3-[N'-(2-oxo-1,3-dihydroindol-3-ylidene)hydrazino-4-aroyl-6-tolylpyridazine which was treated with sulphamethoxazole to yield the sulpha-drug. The novel synthesized compounds were evaluated in regard to their antibacterial activity by the agar plate diffusion method. They showed a significant antibacterial activity against Staphylococcus aureus, Bacillus subitilis, E. coli, Pseudomonas aeruginosa and Yersinia enterocolitica bacteria.