Mohamed Takhi, C Murugan, M Munikumar
2006
Citations
0
Influential Citations
11
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Novel oxazolidinone antibacterials containing N-hydroxyacetamidine moiety are synthesized with the diversity at C-5 terminus. These compounds have been evaluated against a panel of clinically relevant gram-positive and gram-negative pathogens. Most of the analogs in this series displayed activity superior to Linezolid and in vivo efficacies of selected oxazolidinones are also disclosed herein.