Hanan M. Refaat, A. A. Moneer, Omneya M. Khalil
Nov 1, 2004
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Influential Citations
78
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Quality indicators
Journal
Archives of Pharmacal Research
Abstract
In this study, certain 3-methyl-2-[4-(substituted amino carbonyl)anilino] quinoxalines, (2a-d) and (3a-d), were synthesized from the new key compound 2-[4-(ethoxycarbonyl)anilino]-3-methyl quinoxaline (1). In addition, a series of 2-[4-(arylidene hydrazinocarbonyl)anilino]-3-methyl quinoxalines (5a-e), as well as their cyclized oxadiazolinyl derivatives (6a-e), and a series of 2-[4-N-acylhydrazinocarbonyl anilino]-3-methyl quinoxalines (7a-d), as well as their cyclized oxadiazoiyl derivatives (8a-d) were also prepared. Some of these derivatives were evaluated for antimicrobial activityin vitro. It was found that all the selected compounds exhibit antimicrobial activity and that compound5b had a broad spectrum of activity.