Shohei Hamada, Tae-Dong Kim, Takayoshi Suzuki
May 15, 2009
Citations
4
Influential Citations
114
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted histone lysine methylating activity in cellular assays.