V. V. Musiyak, D. Gruzdev, M. Kravchenko
Jan 1, 2019
Citations
0
Influential Citations
9
Citations
Journal
Mendeleev Communications
Abstract
Novel purin-6-yl, 2-aminopurin-6-yl and N-(purin-6-yl)glycyl derivatives of (S)-lysine and (S)-ornithine with free α-functional groups, as well as compounds containing N9-(2-hydroxy-ethoxy)methyl substituent in the purine core have been synthesized and tested for their inhibitory effect against Mycobacterium tuberculosis strains. Among the synthesized conjugates, one compound exhibiting a significant level of antimycobacterial activity has been found.