F. Hanafy
Mar 28, 2011
Citations
0
Influential Citations
15
Citations
Journal
European Journal of Chemistry
Abstract
Some new pyrido[2,3- d ]pyrimidine derivatives ( 3a-c ) were synthesized from 2-amino-5-cyano-6-methoxy-4-(4-methoxyphenyl)pyridine-3-carboxamide. 7-methoxy-5-(4-methoxy phenyl)-4-oxo-2-phenyl-3,4-dihydropyrido[2,3- d ]pyrimidine-6-carbonitrile ( 3b ) and 7-met-hoxy-5-(4-methoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3- d ]pyrimidine-6-carbonitrile ( 3c ) are used in synthesizing 7a,b , then 8a,b . 7-methoxy-5-(4-methoxyphenyl)-2-methyl-4-oxo-3,4-dihydropyrido[2,3- d ]pyrimidine-6-carbonitrile ( 3a ) and 4-hydrazinyl-7-methoxy-5-(4-methoxyphenyl)pyrido[2,3- d ]pyrimidine-6-carbonitrile ( 8b ) were condensed with different carbonyl compounds to produce compounds 4 , 5 , 6 and 9 , 10 , 11 , 12 . 3-Methoxy-1-(4-methoxyphenyl)-6-phenyl-7-hydropyridino[2,3- d ]1,2,3,4-tetrazolo[1,5-e]pyrimidine-2-carbo-nitrile ( 13 ) was synthesized from 8a or 7a . Condensation of 8b with acetophenone to yield 14 , which on further reaction gave 15 then 16 . 4-Hydrazinyl-7-methoxy-5-(4-methoxyphenyl)-2-phenylpyrido[2,3- d ]pyrimidine-6-carbonitrile ( 8a ) also condensed with 4-amino antipyrine giving 17 then 18 . Structures of these compounds have been deduced upon the basis of elemental analysis and spectral data. Significant antifungal activities were observed for some of the synthesized compounds.