E. M. Birinberg, G. D. Glebova, N. A. Andreeva
Jun 1, 1969
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
Conclusions1.2,4-Dihydroxy-6-methylpyrimidine analog of folic acid and 2,4-dihydroxy-6-methyl-,2,4-dihydroxy-2,4-diamino-,2-methyl-4-aminopyrimidine analogs have been synthesized and tested for antimetabolic activity.2.The high activity of 2,4-dihydroxy-6-methylpyrimidine analogs of pteroic and folic acids with the inhibition of dihydrofolic acid reductase from rat liver has been demonstrated.3.The presence of a glutamic acid residue in 2,4-dihydroxy- and 2,4-diamino analogs somewhat decreases the antimetabolic activity, and in a compound with a methyl group in position 2 of the pyrimidine ring, the residue increases the activity.