V. K. Pandey, M. Joshi, Meenal Tandon
2000
Citations
0
Influential Citations
3
Citations
Journal
Acta Pharmaceutica
Abstract
N-[hydroxyethyl]-4-methyl-7-hydroxy carbostyryl (1) was prepared by condensing 4-methyl-7-hydroxy coumarin with 2-aminoethanol in pyridine. Reaction of 1 with benzoic acid in conc. H 2 SO 4 afforded N-[ethyl--meta-carboxyphenyl]-4-methyl-7-hydroxy carbostyryl (2) which upon treatment with benzoin in polyphosphoric acid (PPA) yielded 7-[N'-ethyl-2'-oxo-4-methyl-7'-hydroxyquinolinyl]-3,4-diphenyl isocoumarin (3). Interaction of 3 with aromatic primary amines in pyridine resulted in 7-[2'-oxo-4'-methyl-7'-hydroxy-N-ethylquinolinyl]-1--oxo-2-aryl-3,4-diphenyl isoquinolines (4). Antiviral activity of the latter compounds was evaluated upon Japanese encephalitis virus (JEV) and Herpes simplex virus (HSV) activity on viro cells in vitro and in vivo.