P. Sharma, M. Kumar, S. Vats
Jul 10, 2011
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Journal
Medicinal Chemistry Research
Abstract
Structurally diverse morpholinyl/piperazinylbenzothiazines have been synthesized in quantitative yields by the reaction of substituted 1,4-benzothiazines with morpholine/N-(2-hydroxyethyl)piperazine. 1,4-Benzothiazines were prepared by the reaction of substituted 2-aminobenzenethiols with β-ketoesters. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E.coli and Bacillus cereus. Some of the synthesized compounds have shown significant activity against microorganisms.