A. Stana, B. Tiperciuc, M. Duma
2014
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Journal of The Serbian Chemical Society
Abstract
A series of new 5-(2,6-dichlorobenzylidene)thiazolidine-2,4-dione and 5-(4-methoxybenzylidene)thiazolidine-2,4-dione derivatives (3a-h and 5a-h, respectively) were synthesized starting from 5-arylidenethiazolidine- -2,4-dione and α-halo-ketones. The structural elucidation of the newly syn- thesized compounds was based on elemental analysis and spectroscopic data (MS, 1 H-NMR and 13 C-NMR). The synthesized compounds were screened in vitro for their antimicrobial activities against several pathogenic strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans), as growth inhibition diameters. Some of the compounds displayed better inhibitory activities than that of the reference drug against the Gram- -positive Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes bacterial strains, and showed good antifungal activity against C. albicans, while the antibacterial activity against the Gram-negative Escherichia coli and Salmonella typhimurium bacterial strains was moderate.