Miyeon Jang, S. de Jonghe, Kristien Van Belle
Feb 1, 2010
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Influential Citations
16
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Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
The synthesis of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidines is described. The synthetic route allows introducing structural variety at positions 2, 4 and 6 of the scaffold. Evaluation of their immunosuppressive activity in a Mixed Lymphocyte Reaction (MLR) assay revealed that the most potent compound has an IC(50)-value of 66 nM and therefore deserves attention for further medicinal chemistry optimization.