A. Marini, F. Da Settimo, S. Salerno
May 1, 2008
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Influential Citations
12
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Quality indicators
Journal
ChemInform
Abstract
The synthesis of new planar benzo[3′,2′:5,6]thiopyrano[4,3-d]pyrimidine derivatives, carrying different side groups in the 2 position, is described. The novel substituted pyrimidines were obtained by reaction of the key intermediate 3-dimethylamino methylen-7-methoxy-2,3-dihydrobenzo[3′,2′:5,6]thiopyran-4(4H)-one, characterized by a reactive group adjacent to the CO function, with the suitable binucleophile amidines in a basic medium. All the new compounds were evaluated for the antiproliferative ability by an in vitro assay on two human tumour cell lines (HL-60 and HeLa), and the 2-phenyl substituted derivative showed the capacity to inhibit cell growth on HL-60. Linear flow dichroism measurements indicated the inability to form a molecular complex with DNA.