O. V. Surikova, A. G. Mikhailovskii, G. A. Aleksandrova
Jul 7, 2010
Citations
0
Influential Citations
6
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Reactions with 2,3-dioxopyrrolo[2,1-a]isoquinolines with amines and arylhydrazines were used to synthesize the corresponding amides and hydrazides of 2-oxo-3-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-1-idene)propanoic acid. A number of the resulting compounds were found to have antifungal activity against Candida albicans, the most active being the amide containing a thymol radical, which was active at a concentration of 125 μg/ml.