G. Parameshwarappa, J. Lingamani,, S. Patil
2009
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0
Influential Citations
7
Citations
Journal
Heterocyclic Communications
Abstract
A series of some innovative 7-((4-substituted thiazol-2-yl) methoxy)-4-methyl-2H-chromen-2-one (4a-d) & (6a-b) were synthesized starting from ethyl 2-(4-methyl-2-oxo-2H-chromone-7-yloxy)acetate (la). Reaction of compound (la) with aqueous ammonia yielded 2-(4-methyl-2-oxo-2H-chromomen-7-yloxy)acetamide (2a). Compound (2a) on reaction with P2SS in dioxane gave 2-(4-tnethyl-2-oxo-2H-chromomen-7yloxy) ethanethioamide (3a). Reaction of (3a) with different substituted phenacylbromide/ dichloroacetone afforded (4a-d) & (5a). Condensation of (5a) with different secondary amines gave desired compounds (6a-b). The newly synthesized compounds are characterized by IR, Ή NMR and mass spectral studies. These synthesized compounds were also screened for their antibacterial and antifungal activities.