A. Parekh, K. Desai
Apr 1, 2006
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Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
The synthesis of 1-[(2'-hydroxy-4'-isopropoxy-5'-nitrophenyl)-ethanonc]-4-(aryl)-3-thiosemicarbazones are carried out by refluxing 4-aryl-3-thioscmicarbazides and 2-hydroxy-4-isopropoxy-5-nitroacetophenone in stoichiometric amounts dissolved in aqueous ethanol in presence of few drops of acetic acid. All the compounds have been screened for their antibacterial activity against Gram positive bacteria Bacillus subtilis, Staphylococcus aureus and Gram negative bacteria Escherichia coli and Salmonella typhi. In the primary screening, some of the compounds exhibit appreciable activity. The structures of the synthesized compounds 3a-h have been characterized on the basis of their elemental analysis and spectral data.