Tao Yuan
2012
Citations
0
Influential Citations
0
Citations
Journal
Applied Chemical Industry
Abstract
3-Methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride was synthesized from 2-bromo-1-(3-fluorophenyl)-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidified by divergent synthetic method,with yield of 70.6%.Its structure was confirmed by IR and 1H NMR.Their antidepressant activities were tested with mice forced swimming test.The compound is worth to the further investigate in antidepressant activity.