C. Ziegler, D. Moran, T. J. Fenton
Mar 1, 1990
Citations
0
Influential Citations
5
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A one-pot synthesis of ethyl 8,9-difluoro-6-oxo-6H-benzo[c]quinolizine-5-carboxylate 11 has been developed. The condensation of ethyl 2-pyridylacetate and 2,4,5-trifluorobenzoyl chloride followed by intramolecular nucleophilic aromatic substitution gave the desired ring system. This intermediate was converted to the title compound and its in vitro biological activity is reported.