Zhang Xiao-qing
2007
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Adefovir dipivoxil was synthesized by reaction of adenine and ethylene carbonate to give 9-(hydroxyethyl)adenine, which was subjected to condensation with 4-toluenesulfonic acid diethoxyphosphorylmethyl ester (6) in presence of NaH, hydrolysis and then acylation with an overall yield of 18%(base on adenine). Compound 6 was prepared from diethyl phosphate and paraformaldehyde by condensation and esterification.