Li Zhong-jun
2003
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To synthesize ranolazine, a novel antianginal agent which inhibits partial fatty acid oxidation, reduces myocardical infarct size and cardiac troponin release. Method Exploiting o-methoxyphenol, 2, 6-dimethylaniline, piperazine and epoxychloropropane as starting materials, ranolazine was prepared through a 4-step procedure. Result and Conclusion Ranolazine dihydrochloride was prepared in a good yield. The structure of the target compound was confirmed by MS, 1H-NMR, 13C-NMR spectra and elemental analy-