E. Taylor, P. J. Harrington, S. Fletcher
Jul 1, 1985
Citations
1
Influential Citations
126
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.