S. M. Vahdat, R. Baharfar, M. Tajbakhsh
Nov 10, 2008
Citations
1
Influential Citations
93
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Journal
Tetrahedron Letters
Abstract
Abstract A new and highly flexible procedure is described for the synthesis of α-amino- and α-hydroxy phosphonates. In the presence of a catalytic amount of oxalic acid (10 mol %), trimethyl phosphite reacts with aldehydes or imines (generated in situ from an aldehyde and an amine) to yield the corresponding coupled products in good yield.