Shiyu Wang, F. Liu, J.-M. Fang
Sep 1, 2019
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Journal
Mendeleev Communications
Abstract
A new 5′-dimethoxytrityl N6-alkynylated 2′-deoxyadenosine phosphoramidite has been designed and synthesized from 2′-deoxyadenosine. The applicability of this building block for the production of alkyne-modified oligodeoxynucleotide has been demonstrated. This allows one to introduce various labels into DNA using the click reaction.