J. Carretero, J. Davies, J. Marchand‐Brynaert
1990
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
Bulletin de la Société Chimique de France
Abstract
New alpha, beta-epoxysulfonic acid derivatives 2, 17 and 18, topologically related to monobactams, have been prepared by epoxidation of alpha, beta-unsaturated sulfonates. These were readily obtained from (2R)-N-acylalaninals 7 or protected (syn)-3-hydroxy-2-methylbutanal 24 (+/-) and phosphonate reagents 11 or 12. Compounds 2 and 18 showed no biological activity but the betaine 15 showed a weak anti-beta-lactamase activity.