Yan Yife
2014
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Amifostine was synthesized from acrylamide by addition with ethanolamine and reduction with sodium borohydride to give N-(2-hydroxyethyl)-l,3-propanediamine,which was subjected to salt formation and chlorination with Vilsmeier reagent prepared by SOCl_2 and DMF to afford N-(2-chloroethyl)-l,3-propanediamine dihydrochloride,followed by condensation with sodium thiophosphate dodecahydrate with an overall yield of about 54%(based on acrylamide).