Mao Yuanhu, T. Lei, Wang Jianta
2014
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Guangzhou Chemical Industry
Abstract
Amifostine , a cytoprotector , was synthesized by reaction of 2 -Aminoethanol with acrylonitrile and via condensation, bromination, salification, and purified.The structures of the intermediates and final product were characterized by IR and 1 HNMR, and the purity was measured via HPLC by contrast with standard substance.By optimizing each step , the total yield was raised to 37.3%and purity of 99.2%.