S. Krasnikov, Tatiana A. Obuchova, O. A. Yasinskii
Jan 19, 2004
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient synthesis of 4-(1-adamantyl)benzoic acid based on transition metal ion catalyzed oxidation of 4-(1-adamantyl)toluene has been developed. As a catalytic system, cobalt–manganese bromide with addition of manganese acetate was used. A series of amino acid derivatives of 4-(1-adamantyl)benzoic acid was then synthesized and characterized. These derivatives are novel intermediates potentially useful in the design of therapeutically active peptidomimetics with improved pharmacokinetic and pharmacodynamic parameters.