M. K. Parai, G. Panda
Aug 19, 2009
Citations
0
Influential Citations
59
Citations
Journal
Tetrahedron Letters
Abstract
A series of 3,4-dihydro-2H-benzo[b][1,4]thiazine derivatives 8a–g were synthesized via- a copper-catalyzed intramolecular N-aryl amination reaction on substituted 2-(2-bromophenylthio)-ethanamines which were synthesized by the nucleophilic substitution reaction of 2-bromobenzenethiol with Boc-protected amino alcohol derivatives. This strategy provides a short and an efficient entry to (S)-3-methyl-1,4-benzoxazine 12, an advanced synthetic intermediate for the synthesis of levofloxacin.