A. M. Gellett, P. Huber, P. J. Higgins
Sep 1, 2008
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0
Influential Citations
19
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Journal
Journal of organometallic chemistry
Abstract
The synthesis of a new unnatural amino acid, Nα-Ne-(ferrocene-1-acetyl)-l-lysine, was achieved by coupling a ferroceneacetic acid molecule onto the side chain amine of a lysine. The structure of the compound provides options for incorporation of the molecule into peptides or large proteins. In addition, Nα-Ne-(ferrocene-1-acetyl)-l-lysine exhibits nuclease activity. It is expected that incorporation of this ferrocenyl amino acid into any nucleic acid-binding protein will endow the protein with nuclease capability.