W. McCall, T. A. Grillo, D. Comins
Jun 27, 2008
Citations
0
Influential Citations
19
Citations
Journal
Organic letters
Abstract
Multisubstituted piperidines containing a phenyl group at C-2 can be opened regio- and stereoselectively with cyanogen bromide. The ring-opened products contain useful cyanamide and benzylic bromide functional groups. This methodology is useful for the stereoselective synthesis of uniquely substituted alkylamine derivatives containing multiple chiral centers and various functionality.