Hongming Chen, S. Withers
Sep 1, 2018
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Influential Citations
14
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Journal
Carbohydrate research
Abstract
Azide- and amine-substituted sugars can be useful tools in the probing of biological systems as well as in the assembly of libraries of derivatives using click chemistry or simple amine coupling approaches. A collection of methylumbelliferyl glycosides of various azido- and amino-deoxy sugar derivatives of glucose, galactose and xylose was synthesised via azide displacement of the corresponding triflate derivatives and subsequent modification. These compounds will be used as substrates in a high-throughput screen to identify glycosidases that can process such modified sugars. The α-glycosyl fluoride derivatives of each modified sugar were also synthesised to serve as substrates for glycosynthases derived from the enzymes identified in the screen.