G. Schwertz, Andrea Zanetti, Marllon Nascimento de Oliveira
Feb 8, 2019
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron
Abstract
Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography.