A. Makhlouf, Y. Maklad
Jan 1, 2004
Citations
1
Influential Citations
10
Citations
Journal
Arzneimittelforschung
Abstract
Summary A variety of novel N-arylidene-N’-[5-(4-isobutylphenyl)-[1,2,4] – triazin-3-yl] hydrazines 4, carboxylic acid N’-[5-(4-isobu-tylphenyl)-[1,2,4]-triazin-3-yl]hydrazides 5, triazolotriazines 6 and other related triazine derivatives were synthesized. Several synthetic routes were employed to access the desired compounds from 5-(4-isobutylphenyl)-[1,2,4]-triazin-3-yl hydrazine 3 as a parent compound. The analgesic and anti-inflammatory activities of the synthesized compounds were studied. The results showed that compound 4g exhibited pronounced analgesic activity, while compound 4f displayed the highest anti-inflammatory activity. Meanwhile, compound 6d evoked dual analgesic-anti-inflammatory effect without any ulcerogenicity.