R. Allan, G. Johnston, R. Kazlauskas
1983
Citations
0
Influential Citations
9
Citations
Journal
Australian Journal of Chemistry
Abstract
5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one (4) has been synthesized as a GABA analogue in five steps from hex-3-enedioic acid, the enolic α-keto group being introduced under mild conditions by means of a singlet oxygen cleavage of an enamino lactone. The compound showed negligible activity as a GABA agonist with respect to inhibition of [3H]GABA binding, uptake and trans amination in rat brain membranes