Wang Huiqion
2000
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0
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Journal
Nuclear Techniques
Abstract
A Grignard reagent prepared from n-heptyl bromide was carbonated with the carbon-1-~(13)C dioxide liberated from barium carbonate-1-~(13)C and concentrated sulfuric acid. The octanoic-1-~(13)C acid was obtained by acidic hydrolysis and purified by extraction. The yield was more than 90%. To analyze the structure and compute the ~(13)C abundance of the octanoic-1-~(13)C acid, various analysis of MS, IR, ~1H-NMR and ~(13)C-NMR were performed. According to the quality demand of the oral drug, the quantitative measurements of some metallic elements had also been carried out.