J. Holmes, Gary C. M. Lee, M. Wijono
May 27, 1994
Citations
0
Influential Citations
15
Citations
Journal
Journal of medicinal chemistry
Abstract
A series of 4-substituted 2-thiophenesulfonamides was prepared from 3-thiophenecarboxaldehyde using metalation chemistry developed for 3-furaldehyde. Several of these compounds inhibit carbonic anhydrase II in vitro at concentrations of less than 10 nM. In addition, none of these compounds exhibit sensitization potential as determined from in vitro measurement of cysteine reactivity.