Xiong Jun
2001
Citations
0
Influential Citations
0
Citations
Journal
Journal of Sichuan Normal University
Abstract
In this paper, a practical synthetic method has been reported for the synthesis of S ( ) 3 (4 phenyl 1 piperazinyl) 1,2 propanediol (Levodropopizine): the reaction of aniline with bis (2 hydroxyethyl) amine in the catalysis of hydrochloric acid gives 1 phenylpiperazine which further reacted with 3 chloro 1,2 propanediol to give 3 (4 phenyl 1 piperazinyl) 1,2 propanediol. Through resolution with tartaric acid, the optic pure S isomer was got. This route has the advantages of available starting materials, easy operation, and low cost.