V. A. Gorpinchenko, E. A. Yatsynich, D. V. Petrov
Jun 1, 2005
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
Exo-2-amino-exo-3-aminomethylbicyclo[2.2.1]heptane (I) and 5-amino-exo-3-azatricyclo[5.2.1.02,6]decan-4-one (II) were synthesized and characterized with respect to antiarrhythmic activity. Compound II exhibited antiarrhythmic activity with ED50 = 0.28 and 0.33 mg/kg on the aconitine and calcium chloride models of arrhythmia, respectively. Compound I did not show antiarrhythmic activity and exhibited acute toxicity corresponding to LD50 = 450 mg/kg.