A. M. Likhosherstov, S. Kryzhanovskii, G. Mokrov
Jul 1, 2014
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Journal
Pharmaceutical Chemistry Journal
Abstract
A series of new substituted N-[2-(1-adamantylamino)-2-oxoethyl]-N-(ω-aminoalkyl)nitrobenzamides with an original spectrum of antiarrhythmic activity were synthesized. Their structure—activity relationship was studied. The most active compound, N-[2-(1-adamantylamino)-2-oxoethyl]-N-[3-(diethylamino)propyl]-4-nitrobenzamide hydrochloride, was selected as a potential lead drug for further detailed pharmacological and toxicological studies.