Dejiang Li, Xiucheng Bi, Heqing Fu
Apr 19, 2007
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Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
1,4-Bis[(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl]butanes (2a–o) were synthesized in high yields by cyclization of 3-aryl-4-amino-5-mercapto-1,2,4-triazoles (1a–o) with hexanedioic acid in the presence of POCl3 and tetrabutylammonium iodide as a catalyst. The newly prepared compounds were characterized by analytical and IR, 1H NMR, and EI-MS spectral analysis. The preliminary antibacterial tests showed that most of them were effective against Staphylococcas aureus, Escherichia coli, and Bacillus subtilis. Compounds 2d, 2n, and 2o exhibited promising antibacterial activity.