H. Taniyama, F. Miyoshi, Y. Sano
Jun 10, 1959
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Journal
Chemical & Pharmaceutical Bulletin
Abstract
L-Cystine dihydrazide and L-cystine bis (p-alkoxyanilide) derivatives listed in Tables I, II, and III were prepared and submitted to antibacterial tests with Mycobacterium tuberculosis. Two methods were used for the synthesis of these compounds. The one was du Vigneaud's method and the other was a new route to cysteinyl peptides. In the antibacterial test in vitro, the strongest activity among these compounds was found in L-cystine bis (isonicotinoylhydrazide) which was inhibitory in a concentration of 0.1γ/cc. L-Cystine bis (p-pentyloxyanilide) showed antibacterial action in the range of 1∼0.3γ/cc.