V. Krylov, S. V. Moiseev, A. Kutin
Mar 1, 2016
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Journal
Pharmaceutical Chemistry Journal
Abstract
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.