A. Ivanova, Y. Burgart, V. I. Saloutin
Oct 24, 2013
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Chemistry of Heterocyclic Compounds
Abstract
Alkylation of 4-aryldiazenylpyrazoles using (4-bromobutyl)acetate and [(2-acetoxyethoxy)methyl]-acetate gave the corresponding 1-(4-acetoxybutyl)- and 1-[(2-acetoxyethoxy)methyl]pyrazoles. 3-Fluoroalkyl-4-aryldiazenylpyrazoles react with (4-bromobutyl)acetate to form a mixture of the regio-isomeric 1-(4-acetoxybutyl)-3- and 1-(4-acetoxybutyl)-5-fluoroalkylpyrazoles. Several of the acetoxy- pyrazole derivatives were deacylated and isolated using HPLC. Modest activity towards the ATCC 6633 strain of bacteria Bacillus subtilis has been found for 1-(4-hydroxybutyl)-5-methyl-4-[(4-methyl-phenyl)diazenyl]-3-(octafluorobutyl)-1H-pyrazole.