L. Qiang
2008
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Journal
Fine chemicals
Abstract
Seven N-benzoyl-3-oxobenzo[d]isothiazole-2(3H)-carbothioamide derivatives were synthesized through the reaction of benzoyl isothiocyanate compounds and 1,2-benzisothiazol-2(3H)-one,and their antimicrobial activity was evaluated.Structures of the new compounds were confirmed by IR,MS,1HNMR and 13CNMR.Assayed in vitro for their antimicrobial activity against Vibrio anguillarum,Vibrio mimicus,Vibro alginolyicus,Escherichia coli and Aeromonas hydrophila,the inhibition of solutions of the compounds(0.005 mol/L) against bacteria ranges from 40.5% to 100%.