Xu Rui-bo
2011
Citations
0
Influential Citations
0
Citations
Journal
Chemistry World
Abstract
A new Schiff base bis(4-dimethylaminobenzaldehyde)-[1,4-bis(3-aminopropyl)piperazine] was synthesized by the condensation reaction of 4-dimethylaminobenzaldehyde and 1,4-bis(3-aminopropyl)-piperazine.The optimal synthetic conditions obtained by orthogonal experiment were as follows: reaction temperature of 50℃,reaction time of 4 h,and the mole ratio 4-dimethylaminobenzaldehyde to 1,4-bis(3-aminopropyl)piperazine of 2.1∶1.The yield of the title product was about 83.7%.The antibacterial activity was investigated by agar diffusion method,and the results indicated that the Schiff base was active against Staphyloccus aureus,Escherichia coli and Bacillus subtilis.